MS4A3

Protein identityUniProt · HPA

UniProt accession

Q96HJ5

Gene

MS4A3

Ensembl

ENSG00000149516

Chromosome

11

Canonical length

214 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q96HJ5|MS4A3
     1  MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV LGAIQILNAA
    61  MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC SSGTLSVVAG IKPTRTWIQN
   121  SFGMNIASAT IALVGTAFLS LNIAVNIQSL RSCHSSSESP DLCNYMGSIS NGMVSLLLIL
   181  TLLELCVTIS TIAMWCNANC CNSREEISSP PNSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

397 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.4

gnomAD pLI

0

gnomAD missense Z

-0.49

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• perinuclear region of cytoplasm
• plasma membrane
• specific granule membrane

Protein domainsUniProt · Pfam · InterPro

• CD20-like, transmembrane domain
• Membrane-spanning 4-domains subfamily A
• CD20-like family

KeywordsUniProt

• Cytoplasm
• Membrane
• Receptor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MS4A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDKN3