Seroatlas · Human Serome Atlas

MS4A5

Membrane-spanning 4-domains subfamily A member 5

Also known as: CD20L2, MS4A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3V2
Gene: MS4A5
Ensembl: ENSG00000166930
Chromosome: 11
Canonical length: 200 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q9H3V2|MS4A5
     1  MDSSTAHSPV FLVFPPEITA SEYESTELSA TTFSTQSPLQ KLFARKMKIL GTIQILFGIM
    61  TFSFGVIFLF TLLKPYPRFP FIFLSGYPFW GSVLFINSGA FLIAVKRKTT ETLIILSRIM
   121  NFLSALGAIA GIILLTFGFI LDQNYICGYS HQNSQCKAVT VLFLGILITL MTFSIIELFI
   181  SLPFSILGCH SEDCDCEQCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

testis: 42 nTPM
duodenum: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 1,493 nCPM
early spermatids: 676 nCPM
late primary spermatocytes: 379 nCPM
peritubular myoid cells: 3.4 nCPM
endometrial ciliated cells: 3.3 nCPM
podocytes: 3.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
midbrain: 0.2 nTPM
amygdala: 0.1 nTPM
pons: 0.1 nTPM
white matter: 0.1 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A5 as an antibody target. Whether an autoantibody or antibody against MS4A5 could matter depends on whether native MS4A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A5 is annotated at the cell surface, where native MS4A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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