MS4A12
Membrane-spanning 4-domains subfamily A member 12
Also known as: FLJ20217, M4A12_HUMAN, Ms4a10
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NXJ0
- Gene
- MS4A12
- Ensembl
- ENSG00000071203
- Chromosome
- 11
- Canonical length
- 267 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoli,Endoplasmic reticulum,Golgi apparatus,Plasma membrane,Cytosol
OverviewNCBI Gene
The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Canonical amino-acid sequenceUniProt
267 residues, UniProt reviewed canonical sequence.
>Q9NXJ0|MS4A12
1 MMSSKPTSHA EVNETIPNPY PPSSFMAPGF QQPLGSINLE NQAQGAQRAQ PYGITSPGIF
61 ASSQPGQGNI QMINPSVGTA VMNFKEEAKA LGVIQIMVGL MHIGFGIVLC LISFSFREVL
121 GFASTAVIGG YPFWGGLSFI ISGSLSVSAS KELSRCLVKG SLGMNIVSSI LAFIGVILLL
181 VDMCINGVAG QDYWAVLSGK GISATLMIFS LLEFFVACAT AHFANQANTT TNMSVLVIPN
241 MYESNPVTPA SSSAPPRCNN YSANAPKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MS4A12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 239 nTPM
Expression across tissuesHPA
Tissue
- rectum: 239 nTPM
- colon: 219 nTPM
- appendix: 10 nTPM
- smooth muscle: 4.5 nTPM
- seminal vesicle: 0.4 nTPM
- small intestine: 0.3 nTPM
Single-cell type
- colonocytes: 1,080 nCPM
- enteric transient amplifying cells: 18 nCPM
- goblet cells: 12 nCPM
- enteric stem cells: 3.9 nCPM
- neuroendocrine cells: 3.5 nCPM
- endometrial ciliated cells: 2.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.79
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.12
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MS4A12 as an antibody target. Whether an autoantibody or antibody against MS4A12 could matter depends on whether native MS4A12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MS4A12 is annotated at the cell surface, where native MS4A12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MS4A12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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