Seroatlas · Human Serome Atlas

MS4A6A

Membrane-spanning 4-domains subfamily A member 6A

Also known as: CD20L3, M4A6A_HUMAN, MS4A6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2W1
Gene: MS4A6A
Ensembl: ENSG00000110077
Chromosome: 11
Canonical length: 248 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q9H2W1|MS4A6A
     1  MTSQPVPNET IIVLPSNVIN FSQAEKPEPT NQGQDSLKKH LHAEIKVIGT IQILCGMMVL
    61  SLGIILASAS FSPNFTQVTS TLLNSAYPFI GPFFFIISGS LSIATEKRLT KLLVHSSLVG
   121  SILSALSALV GFIILSVKQA TLNPASLQCE LDKNNIPTRS YVSYFYHDSL YTTDCYTAKA
   181  SLAGTLSLML ICTLLEFCLA VLTAVLRWKQ AYSDFPGSVL FLPHSYIGNS GMSSKMTHDC
   241  GYEELLTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

liver: 133 nTPM
lymph node: 126 nTPM
spleen: 125 nTPM
adipose tissue: 88 nTPM
placenta: 82 nTPM
gallbladder: 73 nTPM

Single-cell type

kupffer cells: 3,075 nCPM
macrophages: 792 nCPM
monocytes: 666 nCPM
cdc: 629 nCPM
monocyte progenitors: 556 nCPM
hofbauer cells: 465 nCPM

Immune cell

classical monocyte: 1,399 nTPM
total PBMC: 943 nTPM
myeloid DC: 814 nTPM
plasmacytoid DC: 559 nTPM
basophil: 525 nTPM
intermediate monocyte: 459 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 20 nTPM
choroid plexus: 19 nTPM
pons: 18 nTPM
thalamus: 15 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A6A as an antibody target. Whether an autoantibody or antibody against MS4A6A could matter depends on whether native MS4A6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A6A is annotated at the cell surface, where native MS4A6A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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