Seroatlas · Human Serome Atlas

MS4A18

Membrane-spanning 4-domains subfamily A member 18

Also known as: M4A18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3C1V0
Gene
MS4A18
Ensembl
ENSG00000214782
Chromosome
11
Canonical length
398 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q3C1V0|MS4A18
     1  MTEQVIGANS VPGIIAPDNV HVIQPSNPVA SGNHLQPSEV TTYPISPKVI HCDTGRANLQ
    61  NLLVVNQNSA AGVQSQPIGY QRQYPVGTAS LQTVPGVIQY TQGTTNLQTW PGDLQNPLNA
   121  NPGLTHTSNS SQWNTSFASF TSFNPKKFIN EEVRTLGAIQ ILIGLTHIFS AINPVLYYYP
   181  FVTWLSGYPL WGGLSYIVSG SLSVWAAKDP SPCVVNSSIS FNIISALFAF AGIFIIITDL
   241  SLYYVTTYSK AVSGGLLPFA LLEFILTCVV SHFGCQATCC RQFENVAVIP TVFSFNPANT
   301  TTSPVNATTG PVNAATGPVS ATNGPVNTTI HPVNTTTSPV NTTTSPVNVT TGPVNANIGP
   361  VNVTTGPVNT TTAPAKATTS CVNAIHTSNV PPNPRTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 18 nTPM
  • breast: 5.6 nTPM
  • small intestine: 2.9 nTPM
  • testis: 0.6 nTPM
  • lymph node: 0.2 nTPM
  • epididymis: 0.1 nTPM

Single-cell type

  • late spermatids: 9.2 nCPM
  • enterocytes: 7.5 nCPM
  • early spermatids: 7.2 nCPM
  • late primary spermatocytes: 3 nCPM
  • parietal cells: 1.8 nCPM
  • prostatic glandular cells: 1.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.1 nTPM
  • cerebellum: 0.9 nTPM
  • cerebral cortex: 0.9 nTPM
  • pons: 0.8 nTPM
  • amygdala: 0.7 nTPM
  • basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
1.49

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A18 as an antibody target. Whether an autoantibody or antibody against MS4A18 could matter depends on whether native MS4A18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A18 is annotated at the cell surface, where native MS4A18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MS4A18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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