Seroatlas · Human Serome Atlas

MS4A8

Membrane-spanning 4-domains subfamily A member 8

Also known as: CD20L5, M4A8_HUMAN, MS4A4, MS4A8B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY19
Gene: MS4A8
Ensembl: ENSG00000166959
Chromosome: 11
Canonical length: 250 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q9BY19|MS4A8
     1  MNSMTSAVPV ANSVLVVAPH NGYPVTPGIM SHVPLYPNSQ PQVHLVPGNP PSLVSNVNGQ
    61  PVQKALKEGK TLGAIQIIIG LAHIGLGSIM ATVLVGEYLS ISFYGGFPFW GGLWFIISGS
   121  LSVAAENQPY SYCLLSGSLG LNIVSAICSA VGVILFITDL SIPHPYAYPD YYPYAWGVNP
   181  GMAISGVLLV FCLLEFGIAC ASSHFGCQLV CCQSSNVSVI YPNIYAANPV ITPEPVTSPP
   241  SYSSEIQANK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 186 nTPM

Expression across tissuesHPA

Tissue

small intestine: 186 nTPM
duodenum: 179 nTPM
fallopian tube: 122 nTPM
stomach: 43 nTPM
cervix: 24 nTPM
choroid plexus: 23 nTPM

Single-cell type

endometrial ciliated cells: 1,183 nCPM
respiratory ciliated cells: 872 nCPM
enterocytes: 768 nCPM
neuroendocrine cells: 671 nCPM
epididymal efferent duct ciliated cells: 452 nCPM
fallopian tube ciliated cells: 377 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 12 nTPM
amygdala: 3.4 nTPM
basal ganglia: 2.8 nTPM
cerebral cortex: 2.3 nTPM
hypothalamus: 1.9 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A8 as an antibody target. Whether an autoantibody or antibody against MS4A8 could matter depends on whether native MS4A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A8 is annotated at the cell surface, where native MS4A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...