Seroatlas · Human Serome Atlas

MS4A4A

Membrane-spanning 4-domains subfamily A member 4A

Also known as: CD20L1, M4A4A_HUMAN, MS4A4, MS4A7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JQ5
Gene: MS4A4A
Ensembl: ENSG00000110079
Chromosome: 11
Canonical length: 239 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q96JQ5|MS4A4A
     1  MHQTYSRHCR PEESTFSAAM TTMQGMEQAM PGAGPGVPQL GNMAVIHSHL WKGLQEKFLK
    61  GEPKVLGVVQ ILTALMSLSM GITMMCMASN TYGSNPISVY IGYTIWGSVM FIISGSLSIA
   121  AGIRTTKGLV RGSLGMNITS SVLAASGILI NTFSLAFYSF HHPYCNYYGN SNNCHGTMSI
   181  LMGLDGMVLL LSVLEFCIAV SLSAFGCKVL CCTPGGVVLI LPSHSHMAET ASPTPLNEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

placenta: 59 nTPM
adipose tissue: 40 nTPM
spleen: 30 nTPM
lymph node: 29 nTPM
lung: 26 nTPM
urinary bladder: 26 nTPM

Single-cell type

kupffer cells: 866 nCPM
hofbauer cells: 591 nCPM
macrophages: 576 nCPM
cdc: 298 nCPM
mast cells: 164 nCPM
monocyte progenitors: 164 nCPM

Immune cell

non-classical monocyte: 83 nTPM
intermediate monocyte: 61 nTPM
plasmacytoid DC: 28 nTPM
myeloid DC: 28 nTPM
classical monocyte: 9.9 nTPM
total PBMC: 6 nTPM

Brain region

thalamus: 19 nTPM
cerebral cortex: 16 nTPM
choroid plexus: 16 nTPM
white matter: 15 nTPM
medulla oblongata: 15 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MS4A4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSE1L

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A4A as an antibody target. Whether an autoantibody or antibody against MS4A4A could matter depends on whether native MS4A4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A4A is annotated at the cell surface, where native MS4A4A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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