Seroatlas · Human Serome Atlas

MS4A13

Membrane-spanning 4-domains subfamily A member 13

Also known as: M4A13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5J8X5
Gene: MS4A13
Ensembl: ENSG00000204979
Chromosome: 11
Canonical length: 152 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q5J8X5|MS4A13
     1  MIGIFHIFMW YFLLVLYMGQ IKGAFGTYEP VTYKTGCTLW GIFFIIAGVF LIRVTKYPTR
    61  SGIISTLIIN IICIITTITA VTLTIIELSH FNSVSYRNYG QAKLGREVSR ILLFFYGLEF
   121  SIALTHSIYS CSNLFRRQND LTSVTEEAES TP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

testis: 3.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 89 nCPM
late primary spermatocytes: 39 nCPM
early spermatids: 22 nCPM
early primary spermatocytes: 10 nCPM
retinal horizontal cells: 6 nCPM
undifferentiated spermatogonia: 5.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A13 as an antibody target. Whether an autoantibody or antibody against MS4A13 could matter depends on whether native MS4A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A13 is annotated at the cell surface, where native MS4A13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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