Seroatlas · Human Serome Atlas

MS4A14

Membrane-spanning 4-domains subfamily A member 14

Also known as: DKFZp434H092, FLJ32856, M4A14_HUMAN, MS4A16, NYD-SP21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JA4
Gene
MS4A14
Ensembl
ENSG00000166928
Chromosome
11
Canonical length
679 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>Q96JA4|MS4A14
     1  MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG
    61  TIFALNYIGF SQRLPLVVLT GYPFWGALIF ILTGYLTVTD KKSKLLGQGV TGMNVISSLV
   121  AITGITFTIL SYRHQDKYCQ MPSFEEICVF SRTLFIVLFF LPSDVTQNSE QPAPEENDQL
   181  QFVLQEEFSS DDSTTNAQSV IFGGYAFFKL TLSRSPLVSQ PGNKGREFVP DEQKQSILPS
   241  PKFSEEEIEP LPPTLEKKPS ENMSIQLDST FKQMKDEDLQ SAIVQPSQMQ TKLLQDQAAS
   301  LQVFPSHSAL KLEDISPEDL PSQALPVEGL SEQTMPSKST SSHVKQSSNL TANDLPPQGI
   361  LSQDTSSQDM LFHDMTSQDM QSLDMLSQDT PSHAMPPQDI PSQDMLSQAL SAHAILPEAS
   421  TSHIVQFPEI QHLLQQPPDL QPENTEPQNQ QILQMSYQDI RSEVMEETKE WKSEEELHRR
   481  KSSRRHSLNQ QTKALQYLRR HSLDVQAKGQ KSSKRHSLDQ QSKGWQSPKQ KSLDQQIKDW
   541  LSPKRHSVDK QAQLNQTKEQ LPDQQAEDQQ AKGEQYPEGQ SKDGQVKDQQ TDKEQNSKKQ
   601  TQDQQTEDQP AQEKKSPKGQ FQNVQAEGQQ AQVEKVPKLL CQDSESQIQQ YQFWQFHKGN
   661  LQAGQPRTVN LLAKNPLTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • testis: 69 nTPM
  • lung: 11 nTPM
  • spleen: 9.9 nTPM
  • adipose tissue: 5 nTPM
  • choroid plexus: 4.5 nTPM
  • blood vessel: 4.1 nTPM

Single-cell type

  • late spermatids: 1,200 nCPM
  • early spermatids: 254 nCPM
  • late primary spermatocytes: 113 nCPM
  • macrophages: 33 nCPM
  • monocytes: 26 nCPM
  • microglia: 18 nCPM

Immune cell

  • non-classical monocyte: 8 nTPM
  • intermediate monocyte: 5.5 nTPM
  • classical monocyte: 3.4 nTPM
  • myeloid DC: 1.4 nTPM
  • total PBMC: 0.9 nTPM
  • naive B-cell: 0.3 nTPM

Brain region

  • thalamus: 8.2 nTPM
  • white matter: 6.6 nTPM
  • medulla oblongata: 6.2 nTPM
  • choroid plexus: 6 nTPM
  • pons: 5.5 nTPM
  • cerebral cortex: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A14 as an antibody target. Whether an autoantibody or antibody against MS4A14 could matter depends on whether native MS4A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A14 is annotated at the cell surface, where native MS4A14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MS4A14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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