MS4A1

Protein identityUniProt · HPA

UniProt accession

P11836

Gene

MS4A1

Ensembl

ENSG00000156738

Chromosome

11

Canonical length

297 aa

Protein class

CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Plasma membrane

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>P11836|MS4A1
     1  MTTPRNSVNG TFPAEPMKGP IAMQSGPKPL FRRMSSLVGP TQSFFMRESK TLGAVQIMNG
    61  LFHIALGGLL MIPAGIYAPI CVTVWYPLWG GIMYIISGSL LAATEKNSRK CLVKGKMIMN
   121  SLSLFAAISG MILSIMDILN IKISHFLKME SLNFIRAHTP YINIYNCEPA NPSEKNSPST
   181  QYCYSIQSLF LGILSVMLIF AFFQELVIAG IVENEWKRTC SRPKSNIVLL SAEEKKEQTI
   241  EIKEEVVGLT ETSSQPKNEE DIEIIPIQEE EEEETETNFP EPPQDQESSP IENDSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

631 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MS4A1.

Disease | AllUniProt

Conditions MS4A1 is implicated in, by any mechanism.

• Immunodeficiency, common variable, 5 (CVID5) MIM:613495

Disease | ImmuneIEDB

Conditions an epitope on MS4A1 was assayed in.

• chronic lymphocytic leukemia T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against MS4A1 are reported. Each links to that disease's full target list.

• Pemphigus 50
• Lupus Erythematosus, Systemic 44
• Arthritis, Rheumatoid 26
• Purpura, Thrombotic Thrombocytopenic 20
• Glomerulonephritis, Membranous 19
• Purpura, Thrombocytopenic, Idiopathic 18
• Anemia, Hemolytic, Autoimmune 17
• Multiple Sclerosis 15
• Vasculitis 13
• Granulomatosis with Polyangiitis 12
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 11
• Diabetes Mellitus, Type 1 11
• Encephalomyelitis, Autoimmune, Experimental 10
• Myasthenia Gravis 9
• Neuromyelitis Optica 9
• Pemphigoid, Bullous 9
• Scleroderma, Systemic 8
• Skin Diseases, Vesiculobullous 8
• Proteinuria 7
• Lupus Nephritis 6

Showing 20 of 50 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for MS4A1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

gnomAD missense Z

0.14

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell activation
• B cell differentiation
• B cell proliferation
• B cell receptor signaling pathway
• calcium ion import into cytosol
• cell surface receptor signaling pathway
• humoral immune response
• positive regulation of calcium ion import across plasma membrane
• protein tetramerization
• response to bacterium
• store-operated calcium entry

Molecular functions

• epidermal growth factor receptor binding
• identical protein binding
• immunoglobulin binding
• MHC class II protein complex binding

Cellular components

• cell surface
• external side of plasma membrane
• extracellular exosome
• extracellular space
• nucleoplasm
• plasma membrane
• plasma membrane raft

Protein domainsUniProt · Pfam · InterPro

• CD20-like, transmembrane domain
• Membrane-spanning 4-domains subfamily A
• CD20-like family

KeywordsUniProt

• B-cell activation
• Cell membrane
• Disulfide bond
• Lipoprotein
• Membrane
• Palmitate
• Pharmaceutical
• Phosphoprotein
• Transmembrane
• Transmembrane helix