Translation protein, beta-barrel domain superfamily
IPR009000
Definition
A β-barrel of circularly permuted topology is found in many transcription proteins, including initiation and elongation factors, and also some ribosomal proteins, although in these cases the fold is elaborated with additional structures. The β-barrel domain is represented by domain 2 of the elongation factors EF-Tu PMID:10715211 and eEF1A PMID:11106763, both of which function to recognise and transport aminoacyl-tRNA to the acceptor (A) site of the ribosome during the elongation process, and of EF-G PMID:11054294, which functions in translocating the peptidyl tRNA from the A site to the peptidyl (P) site. This domain is also present in initiation factors, in domain 2 of eIF2 gamma subunit PMID:11927566, and domains 2 and 4 of IF2/eIF5B PMID:11114334, both of which function to transport the initiator methionyl-tRNA to the ribosome. This β-barrel domain may be involved in interactions with the switch 2 region to stabilise the relative orientations of the domains, which undergo functionally important conformational changes between GTP-and GDP-bound states.
29 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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