RPL3L

Protein identityUniProt · HPA

UniProt accession

Q92901

Gene

RPL3L

Ensembl

ENSG00000140986

Chromosome

16

Canonical length

407 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nuclear speckles

OverviewNCBI Gene

This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q92901|RPL3L
     1  MSHRKFSAPR HGHLGFLPHK RSHRHRGKVK TWPRDDPSQP VHLTAFLGYK AGMTHTLREV
    61  HRPGLKISKR EEVEAVTIVE TPPLVVVGVV GYVATPRGLR SFKTIFAEHL SDECRRRFYK
   121  DWHKSKKKAF TKACKRWRDT DGKKQLQKDF AAMKKYCKVI RVIVHTQMKL LPFRQKKAHI
   181  MEIQLNGGTV AEKVAWAQAR LEKQVPVHSV FSQSEVIDVI AVTKGRGVKG VTSRWHTKKL
   241  PRKTHKGLRK VACIGAWHPA RVGCSIARAG QKGYHHRTEL NKKIFRIGRG PHMEDGKLVK
   301  NNASTSYDVT AKSITPLGGF PHYGEVNNDF VMLKGCIAGT KKRVITLRKS LLVHHSRQAV
   361  ENIELKFIDT TSKFGHGRFQ TAQEKRAFMG PQKKHLEKET PETSGDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

884 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL3L.

Disease | AllUniProt

Conditions RPL3L is implicated in, by any mechanism.

• Cardiomyopathy, dilated, 2D (CMD2D) MIM:619371

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cardiomyopathy, dilated, 2D

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.61

gnomAD pLI

0

gnomAD missense Z

-0.69

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of myotube differentiation
• regulation of striated muscle tissue development
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• cytosolic large ribosomal subunit
• membrane
• ribosome

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein uL3
• Translation protein, beta-barrel domain superfamily
• Large ribosomal subunit protein uL3, conserved site
• Ribosomal protein L3, domain 3, archaeal-type superfamily
• Large ribosomal subunit protein uL3, archaea/eukaryota
• Ribosomal protein L3

KeywordsUniProt

• Cardiomyopathy
• Ribonucleoprotein
• Ribosomal protein