Seroatlas · Human Serome Atlas

AARSD1

Alanyl-tRNA editing protein Aarsd1

Also known as: AASD1_HUMAN, AlaXp, MGC2744, PTGES3L-AARSD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTE6
Gene: AARSD1
Ensembl: ENSG00000266967
Chromosome: 17
Canonical length: 412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable Ser-tRNA(Ala) deacylase activity. Predicted to be involved in regulation of translational fidelity. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q9BTE6|AARSD1
     1  MAFWCQRDSY AREFTTTVVS CCPAELQTEG SNGKKEVLSG FQVVLEDTVL FPEGGGQPDD
    61  RGTINDISVL RVTRRGEQAD HFTQTPLDPG SQVLVRVDWE RRFDHMQQHS GQHLITAVAD
   121  HLFKLKTTSW ELGRFRSAIE LDTPSMTAEQ VAAIEQSVNE KIRDRLPVNV RELSLDDPEV
   181  EQVSGRGLPD DHAGPIRVVN IEGVDSNMCC GTHVSNLSDL QVIKILGTEK GKKNRTNLIF
   241  LSGNRVLKWM ERSHGTEKAL TALLKCGAED HVEAVKKLQN STKILQKNNL NLLRDLAVHI
   301  AHSLRNSPDW GGVVILHRKE GDSEFMNIIA NEIGSEETLL FLTVGDEKGG GLFLLAGPPA
   361  SVETLGPRVA EVLEGKGAGK KGRFQGKATK MSRRMEAQAL LQDYISTQSA KE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AARSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 16 nTPM
tongue: 9.9 nTPM
smooth muscle: 5.3 nTPM
colon: 4.3 nTPM
heart muscle: 3.7 nTPM
testis: 3 nTPM

Single-cell type

cardiomyocytes: 24 nCPM
adipocytes: 6.9 nCPM
megakaryocytes: 6.2 nCPM
megakaryocyte-erythroid progenitors: 1.1 nCPM
myonuclei: 1 nCPM
vascular smooth muscle cells: 1 nCPM

Immune cell

plasmacytoid DC: 1.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 2.9 nTPM
cerebral cortex: 2.3 nTPM
white matter: 1.4 nTPM
hypothalamus: 1.3 nTPM
choroid plexus: 1 nTPM
hippocampal formation: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AARSD1 as an antibody target. Whether an autoantibody or antibody against AARSD1 could matter depends on whether native AARSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AARSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AARSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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