Seroatlas · Human Serome Atlas

STX2

Syntaxin-2

Also known as: EPIM, EPM, STX2_HUMAN, STX2A, STX2B, STX2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32856
Gene
STX2
Ensembl
ENSG00000111450
Chromosome
12
Canonical length
288 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear membrane,Vesicles

OverviewNCBI Gene

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P32856|STX2
     1  MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII
    61  LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS
   121  VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI
   181  ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT
   241  DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 24 nTPM
  • colon: 20 nTPM
  • choroid plexus: 19 nTPM
  • blood vessel: 17 nTPM
  • adipose tissue: 16 nTPM
  • heart muscle: 16 nTPM

Single-cell type

  • respiratory ciliated cells: 153 nCPM
  • endometrial ciliated cells: 149 nCPM
  • choroid plexus epithelial cells: 148 nCPM
  • early spermatids: 146 nCPM
  • late spermatids: 145 nCPM
  • fallopian tube ciliated cells: 140 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • white matter: 5.1 nTPM
  • medulla oblongata: 5 nTPM
  • spinal cord: 3.9 nTPM
  • cerebellum: 3.8 nTPM
  • midbrain: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX2 as an antibody target. Whether an autoantibody or antibody against STX2 could matter depends on whether native STX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX2 is annotated at the cell surface, where native STX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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