Seroatlas · Human Serome Atlas

FKBP11

Peptidyl-prolyl cis-trans isomerase FKBP11

Also known as: FKB11_HUMAN, FKBP19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYL4
Gene: FKBP11
Ensembl: ENSG00000134285
Chromosome: 12
Canonical length: 201 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9NYL4|FKBP11
     1  MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL
    61  HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG
   121  KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA
   181  NRPKVSKKKL KEEKRNKSKK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 467 nTPM

Expression across tissuesHPA

Tissue

pancreas: 467 nTPM
salivary gland: 151 nTPM
spleen: 110 nTPM
liver: 85 nTPM
epididymis: 82 nTPM
pituitary gland: 73 nTPM

Single-cell type

plasma cells: 1,300 nCPM
gastric chief cells: 275 nCPM
pancreatic acinar cells: 269 nCPM
decidual stromal cells: 267 nCPM
epididymal principal cells: 262 nCPM
gastric progenitor cells: 151 nCPM

Immune cell

MAIT T-cell: 189 nTPM
gdT-cell: 116 nTPM
memory CD8 T-cell: 93 nTPM
memory CD4 T-cell: 81 nTPM
naive CD8 T-cell: 70 nTPM
memory B-cell: 51 nTPM

Brain region

hypothalamus: 22 nTPM
midbrain: 9.7 nTPM
medulla oblongata: 8.6 nTPM
thalamus: 7.9 nTPM
choroid plexus: 7.8 nTPM
pons: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

peptidyl-prolyl cis-trans isomerase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IFITM5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP11 as an antibody target. Whether an autoantibody or antibody against FKBP11 could matter depends on whether native FKBP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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