Seroatlas · Human Serome Atlas

FKBP1B

Peptidyl-prolyl cis-trans isomerase FKBP1B

Also known as: FKB1B_HUMAN, FKBP12.6, FKBP1L, FKBP9, OTK4, PPIase

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68106
Gene
FKBP1B
Ensembl
ENSG00000119782
Chromosome
2
Canonical length
108 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>P68106|FKBP1B
     1  MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF
    61  EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 74 nTPM
  • hippocampal formation: 69 nTPM
  • cerebral cortex: 62 nTPM
  • amygdala: 59 nTPM
  • cerebellum: 37 nTPM
  • hypothalamus: 32 nTPM

Single-cell type

  • megakaryocytes: 383 nCPM
  • platelets: 129 nCPM
  • esophageal apical cells: 44 nCPM
  • extravillous trophoblasts: 43 nCPM
  • melanocytes: 40 nCPM
  • hepatic stellate cells: 32 nCPM

Immune cell

  • T-reg: 2.8 nTPM
  • eosinophil: 2.2 nTPM
  • naive B-cell: 1.2 nTPM
  • myeloid DC: 1 nTPM
  • total PBMC: 0.5 nTPM
  • basophil: 0.4 nTPM

Brain region

  • hippocampal formation: 40 nTPM
  • basal ganglia: 33 nTPM
  • cerebral cortex: 32 nTPM
  • hypothalamus: 25 nTPM
  • amygdala: 23 nTPM
  • pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0.39
gnomAD missense Z
1.21
DepMap mean gene effect
0.19
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP1B as an antibody target. Whether an autoantibody or antibody against FKBP1B could matter depends on whether native FKBP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBP1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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