FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3
Also known as: FKBP-25, FKBP25, FKBP3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q00688
- Gene
- FKBP3
- Ensembl
- ENSG00000100442
- Chromosome
- 14
- Canonical length
- 224 aa
- Protein class
- Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Canonical amino-acid sequenceUniProt
224 residues, UniProt reviewed canonical sequence.
>Q00688|FKBP3
1 MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV
61 TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD
121 KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL
181 TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDIDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FKBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 398 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 398 nTPM
- tongue: 347 nTPM
- cerebral cortex: 110 nTPM
- heart muscle: 106 nTPM
- basal ganglia: 106 nTPM
- amygdala: 99 nTPM
Single-cell type
- late spermatids: 622 nCPM
- cytotrophoblasts: 411 nCPM
- migrating cytotrophoblasts: 291 nCPM
- esophageal apical cells: 273 nCPM
- thymic myoid cells: 269 nCPM
- esophageal suprabasal cells: 256 nCPM
Immune cell
- plasmacytoid DC: 43 nTPM
- myeloid DC: 33 nTPM
- T-reg: 31 nTPM
- memory B-cell: 30 nTPM
- non-classical monocyte: 30 nTPM
- intermediate monocyte: 27 nTPM
Brain region
- cerebellum: 66 nTPM
- cerebral cortex: 59 nTPM
- white matter: 56 nTPM
- basal ganglia: 50 nTPM
- thalamus: 49 nTPM
- medulla oblongata: 47 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.01
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.02
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FKBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FKBP3 as an antibody target. Whether an autoantibody or antibody against FKBP3 could matter depends on whether native FKBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FKBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FKBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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