FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2
Also known as: FKBP-13, FKBP13, FKBP2_HUMAN, PPIase
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P26885
- Gene
- FKBP2
- Ensembl
- ENSG00000173486
- Chromosome
- 11
- Canonical length
- 142 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Plasma membrane
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Canonical amino-acid sequenceUniProt
142 residues, UniProt reviewed canonical sequence.
>P26885|FKBP2
1 MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL
61 EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK
121 IPGGATLVFE VELLKIERRT ELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FKBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 391 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 391 nTPM
- epididymis: 375 nTPM
- pancreas: 264 nTPM
- liver: 229 nTPM
- pituitary gland: 228 nTPM
- salivary gland: 196 nTPM
Single-cell type
- hepatocytes: 53 nCPM
- other brain neurons: 50 nCPM
- endometrial secretory cells: 46 nCPM
- oligodendrocytes: 41 nCPM
- ependymal cells: 38 nCPM
- astrocytes: 35 nCPM
Immune cell
- plasmacytoid DC: 932 nTPM
- basophil: 278 nTPM
- MAIT T-cell: 231 nTPM
- intermediate monocyte: 192 nTPM
- gdT-cell: 179 nTPM
- memory CD8 T-cell: 177 nTPM
Brain region
- choroid plexus: 125 nTPM
- midbrain: 103 nTPM
- cerebral cortex: 102 nTPM
- pons: 101 nTPM
- medulla oblongata: 98 nTPM
- hypothalamus: 97 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.09
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.99
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FKBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FKBP2 as an antibody target. Whether an autoantibody or antibody against FKBP2 could matter depends on whether native FKBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FKBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FKBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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