FKBP1C
Peptidyl-prolyl cis-trans isomerase FKBP1C
Also known as: FKB1C_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q5VVH2
- Gene
- FKBP1C
- Canonical length
- 108 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for FKBP1C in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
108 residues, UniProt reviewed canonical sequence.
>Q5VVH2|FKBP1C
1 MGVHVETISP GDWRTFPKRS QTCVMHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW
61 EEGVVQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLELocalizationUniProt · AlphaFold · HPA
Whether an antibody against FKBP1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 1.7 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 1.7 nTPM
- adipose tissue: 1.4 nTPM
- lung: 1.1 nTPM
- amygdala: 0.9 nTPM
- breast: 0.9 nTPM
- adrenal gland: 0.8 nTPM
Single-cell type
- esophageal apical cells: 2.1 nCPM
- parietal cells: 1.8 nCPM
- esophageal suprabasal cells: 1.2 nCPM
- gastric chief cells: 1.1 nCPM
- podocytes: 0.8 nCPM
- esophageal basal cells: 0.7 nCPM
Immune cell
- intermediate monocyte: 5.1 nTPM
- non-classical monocyte: 4.7 nTPM
- eosinophil: 4.4 nTPM
- total PBMC: 4.3 nTPM
- classical monocyte: 3.3 nTPM
- myeloid DC: 3 nTPM
Brain region
- cerebral cortex: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
- white matter: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- cerebellum: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0.04
- gnomAD missense Z
- -0.95
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FKBP1C as an antibody target. Whether an autoantibody or antibody against FKBP1C could matter depends on whether native FKBP1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FKBP1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FKBP1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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