Seroatlas · Human Serome Atlas

FKBP9

Peptidyl-prolyl cis-trans isomerase FKBP9

Also known as: FKBP60, FKBP63, FKBP9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95302
Gene: FKBP9
Ensembl: ENSG00000122642
Chromosome: 7
Canonical length: 570 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>O95302|FKBP9
     1  MAFRGWRPPP PPLLLLLLWV TGQAAPVAGL GSDAELQIER RFVPDECPRT VRSGDFVRYH
    61  YVGTFPDGQK FDSSYDRDST FNVFVGKGQL ITGMDQALVG MCVNERRFVK IPPKLAYGNE
   121  GVSGVIPPNS VLHFDVLLMD IWNSEDQVQI HTYFKPPSCP RTIQVSDFVR YHYNGTFLDG
   181  TLFDSSHNRM KTYDTYVGIG WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EDGDGKDIPG
   241  QASLVFDVAL LDLHNPKDSI SIENKVVPEN CERISQSGDF LRYHYNGTLL DGTLFDSSYS
   301  RNRTFDTYIG QGYVIPGMDE GLLGVCIGEK RRIVVPPHLG YGEEGRGNIP GSAVLVFDIH
   361  VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL LDGTLLDSTW NLGKTYNIVL
   421  GSGQVVLGMD MGLREMCVGE KRTVIIPPHL GYGEAGVDGE VPGSAVLVFD IELLELVAGL
   481  PEGYMFIWNG EVSPNLFEEI DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFDAELIVKN
   541  MFTNQDRNGD GKVTAEEFKL KDQEAKHDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 77 nTPM
ovary: 77 nTPM
blood vessel: 76 nTPM
placenta: 76 nTPM
heart muscle: 74 nTPM
smooth muscle: 70 nTPM

Single-cell type

hepatic stellate cells: 90 nCPM
vascular endothelial cells: 85 nCPM
gastric progenitor cells: 76 nCPM
fibroblasts: 68 nCPM
fibro-adipogenic progenitors: 63 nCPM
melanocytes: 58 nCPM

Immune cell

neutrophil: 4.2 nTPM
classical monocyte: 2.3 nTPM
intermediate monocyte: 1.6 nTPM
basophil: 1.1 nTPM
myeloid DC: 0.8 nTPM
eosinophil: 0.6 nTPM

Brain region

hypothalamus: 54 nTPM
midbrain: 47 nTPM
thalamus: 44 nTPM
pons: 44 nTPM
medulla oblongata: 43 nTPM
choroid plexus: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP9 as an antibody target. Whether an autoantibody or antibody against FKBP9 could matter depends on whether native FKBP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...