Seroatlas · Human Serome Atlas

FKBP7

Peptidyl-prolyl cis-trans isomerase FKBP7

Also known as: FKBP23, FKBP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y680
Gene: FKBP7
Ensembl: ENSG00000079150
Chromosome: 2
Canonical length: 222 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q9Y680|FKBP7
     1  MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY
    61  DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG
   121  KEGYAEGKIP PDATLIFEIE LYAVTKGPRS IETFKQIDMD NDRQLSKAEI NLYLQREFEK
   181  DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

ovary: 53 nTPM
endometrium: 26 nTPM
cervix: 22 nTPM
blood vessel: 20 nTPM
smooth muscle: 18 nTPM
gallbladder: 14 nTPM

Single-cell type

early spermatids: 259 nCPM
decidual stromal cells: 168 nCPM
ovarian stromal cells: 88 nCPM
late primary spermatocytes: 76 nCPM
late spermatids: 65 nCPM
hepatic stellate cells: 58 nCPM

Immune cell

myeloid DC: 2.8 nTPM
plasmacytoid DC: 2 nTPM
MAIT T-cell: 1.2 nTPM
T-reg: 1.2 nTPM
memory B-cell: 1.1 nTPM
naive CD4 T-cell: 1 nTPM

Brain region

cerebral cortex: 4.6 nTPM
medulla oblongata: 4.6 nTPM
white matter: 4.6 nTPM
cerebellum: 4.5 nTPM
midbrain: 3.8 nTPM
amygdala: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WFDC2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP7 as an antibody target. Whether an autoantibody or antibody against FKBP7 could matter depends on whether native FKBP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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