Seroatlas · Human Serome Atlas

FKBP1A

Peptidyl-prolyl cis-trans isomerase FKBP1A

Also known as: FKB1A_HUMAN, FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62942
Gene
FKBP1A
Ensembl
ENSG00000088832
Chromosome
20
Canonical length
108 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>P62942|FKBP1A
     1  MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW
    61  EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
326 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 326 nTPM
  • adipose tissue: 290 nTPM
  • lung: 236 nTPM
  • smooth muscle: 210 nTPM
  • placenta: 206 nTPM
  • breast: 202 nTPM

Single-cell type

  • esophageal apical cells: 37 nCPM
  • platelets: 34 nCPM
  • megakaryocytes: 31 nCPM
  • late spermatids: 30 nCPM
  • extravillous trophoblasts: 28 nCPM
  • late primary spermatocytes: 26 nCPM

Immune cell

  • total PBMC: 1,153 nTPM
  • non-classical monocyte: 1,017 nTPM
  • intermediate monocyte: 1,006 nTPM
  • eosinophil: 976 nTPM
  • classical monocyte: 872 nTPM
  • neutrophil: 808 nTPM

Brain region

  • basal ganglia: 244 nTPM
  • hippocampal formation: 222 nTPM
  • cerebral cortex: 187 nTPM
  • amygdala: 161 nTPM
  • hypothalamus: 125 nTPM
  • white matter: 118 nTPM

ReferencesPubMed · IEDB

Publications for FKBP1A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.81
gnomAD missense Z
1.66
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP1A as an antibody target. Whether an autoantibody or antibody against FKBP1A could matter depends on whether native FKBP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBP1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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