Seroatlas · Human Serome Atlas

FKBP10

Peptidyl-prolyl cis-trans isomerase FKBP10

Also known as: FKB10_HUMAN, FKBP6, FKBP65, FLJ20683, FLJ22041, FLJ23833, hFKBP65

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AY3
Gene
FKBP10
Ensembl
ENSG00000141756
Chromosome
17
Canonical length
582 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>Q96AY3|FKBP10
     1  MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ
    61  MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT GMDRGLMGMC VNERRRLIVP
   121  PHLGYGSIGL AGLIPPDATL YFDVVLLDVW NKEDTVQVST LLRPPHCPRM VQDGDFVRYH
   181  YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK
   241  GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG
   301  TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG
   361  SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH
   421  DYGAPQEATL GANKVIEGLD TGLQGMCVGE RRQLIVPPHL AHGESGARGV PGSAVLLFEV
   481  ELVSREDGLP TGYLFVWHKD PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG
   541  QDPEKTIGDM FQNQDRNQDG KITVDELKLK SDEDEERVHE EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 122 nTPM
  • ovary: 76 nTPM
  • cervix: 67 nTPM
  • endometrium: 59 nTPM
  • placenta: 57 nTPM
  • pituitary gland: 57 nTPM

Single-cell type

  • decidual stromal cells: 244 nCPM
  • hepatic stellate cells: 136 nCPM
  • fibroblasts: 102 nCPM
  • endometrial stromal cells: 79 nCPM
  • lactotrophs: 75 nCPM
  • leydig cells: 63 nCPM

Immune cell

  • NK-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 24 nTPM
  • thalamus: 24 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 18 nTPM
  • choroid plexus: 18 nTPM
  • spinal cord: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FKBP10.

Disease | AllUniProt

Conditions FKBP10 is implicated in, by any mechanism.

Disease | GeneticClinVar

81 pathogenic / likely-pathogenic of 694 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP10 as an antibody target. Whether an autoantibody or antibody against FKBP10 could matter depends on whether native FKBP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBP10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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