Seroatlas · Human Serome Atlas

TMEM41B

Transmembrane protein 41B

Also known as: KIAA0033, TM41B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BJD5
Gene: TMEM41B
Ensembl: ENSG00000166471
Chromosome: 11
Canonical length: 291 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Peroxisomes

OverviewNCBI Gene

Enables phospholipid scramblase activity. Involved in autophagosome assembly and intracellular lipid transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q5BJD5|TMEM41B
     1  MAKGRVAERS QLGAHHTTPV GDGAAGTRGL AAPGSRDHQK EKSWVEAGSA RMSLLILVSI
    61  FLSAAFVMFL VYKNFPQLSE EERVNMKVPR DMDDAKALGK VLSKYKDTFY VQVLVAYFAT
   121  YIFLQTFAIP GSIFLSILSG FLYPFPLALF LVCLCSGLGA SFCYMLSYLV GRPVVYKYLT
   181  EKAVKWSQQV ERHREHLINY IIFLRITPFL PNWFINITSP VINVPLKVFF IGTFLGVAPP
   241  SFVAIKAGTT LYQLTTAGEA VSWNSIFILM ILAVLSILPA IFQKKLKQKF E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM41B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

liver: 22 nTPM
duodenum: 17 nTPM
small intestine: 16 nTPM
thyroid gland: 15 nTPM
lung: 15 nTPM
esophagus: 13 nTPM

Single-cell type

neutrophils: 274 nCPM
epididymal principal cells: 266 nCPM
endometrial glandular cells: 262 nCPM
alveolar cells type 2: 258 nCPM
urothelial cells: 222 nCPM
alveolar cells type 1: 212 nCPM

Immune cell

naive CD8 T-cell: 10 nTPM
basophil: 10 nTPM
NK-cell: 9.6 nTPM
plasmacytoid DC: 8.5 nTPM
naive CD4 T-cell: 8.2 nTPM
memory B-cell: 7 nTPM

Brain region

white matter: 31 nTPM
medulla oblongata: 26 nTPM
spinal cord: 25 nTPM
cerebellum: 25 nTPM
midbrain: 24 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.29
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.41
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phospholipid scramblase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM41B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM41B as an antibody target. Whether an autoantibody or antibody against TMEM41B could matter depends on whether native TMEM41B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM41B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM41B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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