Seroatlas · Human Serome Atlas

SLC25A30

Kidney mitochondrial carrier protein 1

Also known as: KMCP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SVS4
Gene: SLC25A30
Ensembl: ENSG00000174032
Chromosome: 13
Canonical length: 291 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Although the outer mitochondrial membrane is permeable to many small metabolites, transport of solutes across the inner mitochondrial membrane is achieved by members of the mitochondrial carrier protein family, such as SLC25A30 (Haguenauer et al., 2005 [PubMed 15809292]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q5SVS4|SLC25A30
     1  MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFKEIRYR GMLHALVRIG
    61  REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLFIER PEDETLPINV ICGILSGVIS
   121  STIANPTDVL KIRMQAQSNT IQGGMIGNFM NIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL
   181  PVYDITKKHL ILSGLMGDTV YTHFLSSFTC GLAGALASNP VDVVRTRMMN QRVLRDGRCS
   241  GYTGTLDCLL QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF VTYEQLKKLD L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 81 nTPM
heart muscle: 67 nTPM
tongue: 59 nTPM
kidney: 39 nTPM
liver: 30 nTPM
ovary: 15 nTPM

Single-cell type

myonuclei: 80 nCPM
distal convoluted tubule cells: 71 nCPM
renal connecting tubule cells: 58 nCPM
hepatocytes: 55 nCPM
cardiomyocytes: 43 nCPM
proximal tubule cells: 37 nCPM

Immune cell

plasmacytoid DC: 2.4 nTPM
eosinophil: 1.9 nTPM
myeloid DC: 1.7 nTPM
intermediate monocyte: 1.4 nTPM
classical monocyte: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

choroid plexus: 16 nTPM
hypothalamus: 11 nTPM
basal ganglia: 10 nTPM
medulla oblongata: 9.9 nTPM
midbrain: 8.7 nTPM
spinal cord: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

inorganic anion transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

VDAC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A30 as an antibody target. Whether an autoantibody or antibody against SLC25A30 could matter depends on whether native SLC25A30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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