Seroatlas · Human Serome Atlas

VASP

Vasodilator-stimulated phosphoprotein

Also known as: VASP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50552
Gene
VASP
Ensembl
ENSG00000125753
Chromosome
19
Canonical length
380 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Focal adhesion sites
Quaternary structure
Homotetramer

OverviewNCBI Gene

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>P50552|VASP
     1  MSETVICSSR ATVMLYDDGN KRWLPAGTGP QAFSRVQIYH NPTANSFRVV GRKMQPDQQV
    61  VINCAIVRGV KYNQATPNFH QWRDARQVWG LNFGSKEDAA QFAAGMASAL EALEGGGPPP
   121  PPALPTWSVP NGPSPEEVEQ QKRQQPGPSE HIERRVSNAG GPPAPPAGGP PPPPGPPPPP
   181  GPPPPPGLPP SGVPAAAHGA GGGPPPAPPL PAAQGPGGGG AGAPGLAAAI AGAKLRKVSK
   241  QEEASGGPTA PKAESGRSGG GGLMEEMNAM LARRRKATQV GEKTPKDESA NQEEPEARVP
   301  AQSESVRRPW EKNSTTLPRM KSSSSVTTSE TQPCTPSSSD YSDLQRVKQE LLEEVKKELQ
   361  KVKEEIIEAF VQELRKRGSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VASP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
170 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 170 nTPM
  • spleen: 111 nTPM
  • tonsil: 109 nTPM
  • urinary bladder: 104 nTPM
  • appendix: 102 nTPM
  • smooth muscle: 102 nTPM

Single-cell type

  • neutrophils: 1,519 nCPM
  • megakaryocytes: 1,113 nCPM
  • extravillous trophoblasts: 691 nCPM
  • neutrophil progenitors: 497 nCPM
  • platelets: 358 nCPM
  • monocytes: 301 nCPM

Immune cell

  • neutrophil: 88 nTPM
  • eosinophil: 84 nTPM
  • non-classical monocyte: 50 nTPM
  • basophil: 47 nTPM
  • intermediate monocyte: 34 nTPM
  • classical monocyte: 18 nTPM

Brain region

  • thalamus: 38 nTPM
  • pons: 34 nTPM
  • medulla oblongata: 32 nTPM
  • cerebral cortex: 31 nTPM
  • white matter: 30 nTPM
  • spinal cord: 30 nTPM

ReferencesPubMed · IEDB

Publications for VASP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.95
gnomAD missense Z
1.21
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VASP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VASP as an antibody target. Whether an autoantibody or antibody against VASP could matter depends on whether native VASP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VASP is annotated at the cell surface, where native VASP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VASP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VASP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...