Seroatlas · Human Serome Atlas

ZYX

Zyxin

Also known as: ZYX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15942
Gene: ZYX
Ensembl: ENSG00000159840
Chromosome: 7
Canonical length: 572 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Focal adhesion sites

OverviewNCBI Gene

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q15942|ZYX
     1  MAAPRPSPAI SVSVSAPAFY APQKKFGPVV APKPKVNPFR PGDSEPPPAP GAQRAQMGRV
    61  GEIPPPPPED FPLPPPPLAG DGDDAEGALG GAFPPPPPPI EESFPPAPLE EEIFPSPPPP
   121  PEEEGGPEAP IPPPPQPREK VSSIDLEIDS LSSLLDDMTK NDPFKARVSS GYVPPPVATP
   181  FSSKSSTKPA AGGTAPLPPW KSPSSSQPLP QVPAPAQSQT QFHVQPQPQP KPQVQLHVQS
   241  QTQPVSLANT QPRGPPASSP APAPKFSPVT PKFTPVASKF SPGAPGGSGS QPNQKLGHPE
   301  ALSAGTGSPQ PPSFTYAQQR EKPRVQEKQH PVPPPAQNQN QVRSPGAPGP LTLKEVEELE
   361  QLTQQLMQDM EHPQRQNVAV NELCGRCHQP LARAQPAVRA LGQLFHIACF TCHQCAQQLQ
   421  GQQFYSLEGA PYCEGCYTDT LEKCNTCGEP ITDRMLRATG KAYHPHCFTC VVCARPLEGT
   481  SFIVDQANRP HCVPDYHKQY APRCSVCSEP IMPEPGRDET VRVVALDKNF HMKCYKCEDC
   541  GKPLSIEADD NGCFPLDGHV LCRKCHTARA QT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZYX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 536 nTPM

Expression across tissuesHPA

Tissue

endometrium: 536 nTPM
blood vessel: 406 nTPM
colon: 359 nTPM
lung: 296 nTPM
fallopian tube: 281 nTPM
urinary bladder: 264 nTPM

Single-cell type

megakaryocytes: 37 nCPM
platelets: 24 nCPM
brain excitatory neurons: 24 nCPM
neutrophils: 19 nCPM
brain inhibitory neurons: 16 nCPM
oligodendrocyte progenitor cells: 15 nCPM

Immune cell

neutrophil: 164 nTPM
non-classical monocyte: 84 nTPM
classical monocyte: 71 nTPM
intermediate monocyte: 70 nTPM
myeloid DC: 59 nTPM
eosinophil: 48 nTPM

Brain region

cerebral cortex: 56 nTPM
thalamus: 48 nTPM
pons: 45 nTPM
white matter: 42 nTPM
medulla oblongata: 41 nTPM
midbrain: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZYX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZYX as an antibody target. Whether an autoantibody or antibody against ZYX could matter depends on whether native ZYX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZYX is annotated at the cell surface, where native ZYX is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZYX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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