Seroatlas · Human Serome Atlas

LPP

Lipoma-preferred partner

Also known as: LPP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q93052
Gene
LPP
Ensembl
ENSG00000145012
Chromosome
3
Canonical length
612 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

612 residues, UniProt reviewed canonical sequence.

>Q93052|LPP
     1  MSHPSWLPPK STGEPLGHVP ARMETTHSFG NPSISVSTQQ PPKKFAPVVA PKPKYNPYKQ
    61  PGGEGDFLPP PPPPLDDSSA LPSISGNFPP PPPLDEEAFK VQGNPGGKTL EERRSSLDAE
   121  IDSLTSILAD LECSSPYKPR PPQSSTGSTA SPPVSTPVTG HKRMVIPNQP PLTATKKSTL
   181  KPQPAPQAGP IPVAPIGTLK PQPQPVPASY TTASTSSRPT FNVQVKSAQP SPHYMAAPSS
   241  GQIYGSGPQG YNTQPVPVSG QCPPPSTRGG MDYAYIPPPG LQPEPGYGYA PNQGRYYEGY
   301  YAAGPGYGGR NDSDPTYGQQ GHPNTWKREP GYTPPGAGNQ NPPGMYPVTG PKKTYITDPV
   361  SAPCAPPLQP KGGHSGQLGP SSVAPSFRPE DELEHLTKKM LYDMENPPAD EYFGRCARCG
   421  ENVVGEGTGC TAMDQVFHVD CFTCIICNNK LRGQPFYAVE KKAYCEPCYI NTLEQCNVCS
   481  KPIMERILRA TGKAYHPHCF TCVMCHRSLD GIPFTVDAGG LIHCIEDFHK KFAPRCSVCK
   541  EPIMPAPGQE ETVRIVALDR DFHVHCYRCE DCGGLLSEGD NQGCYPLDGH ILCKTCNSAR
   601  IRVLTAKAST DL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 128 nTPM
  • smooth muscle: 73 nTPM
  • colon: 67 nTPM
  • endometrium: 54 nTPM
  • urinary bladder: 54 nTPM
  • seminal vesicle: 49 nTPM

Single-cell type

  • smooth muscle cells: 3,744 nCPM
  • late spermatids: 2,886 nCPM
  • vascular smooth muscle cells: 2,741 nCPM
  • salivary myoepithelial cells: 2,478 nCPM
  • cardiomyocytes: 1,775 nCPM
  • pericytes: 1,675 nCPM

Immune cell

  • neutrophil: 19 nTPM
  • naive B-cell: 5.5 nTPM
  • plasmacytoid DC: 5.2 nTPM
  • classical monocyte: 4.9 nTPM
  • gdT-cell: 4.9 nTPM
  • NK-cell: 4.8 nTPM

Brain region

  • choroid plexus: 89 nTPM
  • medulla oblongata: 67 nTPM
  • thalamus: 66 nTPM
  • hypothalamus: 58 nTPM
  • cerebellum: 54 nTPM
  • cerebral cortex: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LPP.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 202 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.01
gnomAD missense Z
-1.5
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LPP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPP as an antibody target. Whether an autoantibody or antibody against LPP could matter depends on whether native LPP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPP is annotated at the cell surface, where native LPP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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