Seroatlas · Human Serome Atlas

PFN2

Profilin-2

Also known as: PROF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P35080
Gene: PFN2
Ensembl: ENSG00000070087
Chromosome: 3
Canonical length: 140 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>P35080|PFN2
     1  MAGWQSYVDN LMCDGCCQEA AIVGYCDAKY VWAATAGGVF QSITPIEIDM IVGKDREGFF
    61  TNGLTLGAKK CSVIRDSLYV DGDCTMDIRT KSQGGEPTYN VAVGRAGRVL VFVMGKEGVH
   121  GGGLNKKAYS MAKYLRDSGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 342 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 342 nTPM
hippocampal formation: 270 nTPM
amygdala: 252 nTPM
skeletal muscle: 252 nTPM
basal ganglia: 216 nTPM
hypothalamus: 177 nTPM

Single-cell type

myonuclei: 71 nCPM
cardiomyocytes: 63 nCPM
early spermatids: 32 nCPM
epicardial cells: 30 nCPM
undifferentiated spermatogonia: 26 nCPM
late primary spermatocytes: 25 nCPM

Immune cell

naive CD4 T-cell: 6.3 nTPM
memory CD4 T-cell: 4.3 nTPM
MAIT T-cell: 4.2 nTPM
naive CD8 T-cell: 4.2 nTPM
memory CD8 T-cell: 3.6 nTPM
gdT-cell: 2.1 nTPM

Brain region

hippocampal formation: 477 nTPM
cerebral cortex: 374 nTPM
basal ganglia: 314 nTPM
white matter: 283 nTPM
hypothalamus: 258 nTPM
amygdala: 230 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.42
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFN2 as an antibody target. Whether an autoantibody or antibody against PFN2 could matter depends on whether native PFN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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