Seroatlas · Human Serome Atlas

RNF167

E3 ubiquitin-protein ligase RNF167

Also known as: DKFZP566H073, RN167_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6Y7
Gene: RNF167
Ensembl: ENSG00000108523
Chromosome: 17
Canonical length: 350 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Mitotic spindle,Centriolar satellite,Cytosol

OverviewNCBI Gene

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9H6Y7|RNF167
     1  MHPAAFPLPV VVAAVLWGAA PTRGLIRATS DHNASMDFAD LPALFGATLS QEGLQGFLVE
    61  AHPDNACSPI APPPPAPVNG SVFIALLRRF DCNFDLKVLN AQKAGYGAAV VHNVNSNELL
   121  NMVWNSEEIQ QQIWIPSVFI GERSSEYLRA LFVYEKGARV LLVPDNTFPL GYYLIPFTGI
   181  VGLLVLAMGA VMIARCIQHR KRLQRNRLTK EQLKQIPTHD YQKGDQYDVC AICLDEYEDG
   241  DKLRVLPCAH AYHSRCVDPW LTQTRKTCPI CKQPVHRGPG DEDQEEETQG QEEGDEGEPR
   301  DHPASERTPL LGSSPTLPTS FGSLAPAPLV FPGPSTDPPL SPPSSPVILV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF167 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 174 nTPM

Expression across tissuesHPA

Tissue

liver: 174 nTPM
choroid plexus: 155 nTPM
skeletal muscle: 151 nTPM
heart muscle: 127 nTPM
skin: 121 nTPM
esophagus: 117 nTPM

Single-cell type

oocytes: 286 nCPM
esophageal apical cells: 214 nCPM
extravillous trophoblasts: 182 nCPM
esophageal suprabasal cells: 161 nCPM
early primary spermatocytes: 150 nCPM
syncytiotrophoblasts: 150 nCPM

Immune cell

eosinophil: 238 nTPM
neutrophil: 221 nTPM
gdT-cell: 196 nTPM
memory CD8 T-cell: 196 nTPM
total PBMC: 177 nTPM
MAIT T-cell: 154 nTPM

Brain region

cerebral cortex: 100 nTPM
white matter: 100 nTPM
thalamus: 96 nTPM
pons: 89 nTPM
cerebellum: 88 nTPM
medulla oblongata: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.03
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF167 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF167 as an antibody target. Whether an autoantibody or antibody against RNF167 could matter depends on whether native RNF167 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF167 is annotated at the cell surface, where native RNF167 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RNF167 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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