Seroatlas · Human Serome Atlas

RNF138

E3 ubiquitin-protein ligase RNF138

Also known as: NARF, RN138_HUMAN, STRIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVD3
Gene: RNF138
Ensembl: ENSG00000134758
Chromosome: 18
Canonical length: 245 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q8WVD3|RNF138
     1  MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN
    61  VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN
   121  FQISQDSVGN SNRSETSTSD NTETYQENTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH
   181  LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES
   241  FQVNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF138 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

testis: 113 nTPM
bone marrow: 91 nTPM
thymus: 27 nTPM
lymph node: 23 nTPM
colon: 22 nTPM
spleen: 20 nTPM

Single-cell type

late spermatids: 7,000 nCPM
early spermatids: 1,096 nCPM
late primary spermatocytes: 310 nCPM
early primary spermatocytes: 187 nCPM
neutrophils: 181 nCPM
neutrophil progenitors: 165 nCPM

Immune cell

naive CD4 T-cell: 103 nTPM
total PBMC: 69 nTPM
naive CD8 T-cell: 67 nTPM
neutrophil: 65 nTPM
classical monocyte: 65 nTPM
eosinophil: 64 nTPM

Brain region

cerebellum: 31 nTPM
white matter: 28 nTPM
choroid plexus: 25 nTPM
basal ganglia: 21 nTPM
midbrain: 21 nTPM
cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.68
gnomAD missense Z: 2.12
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Di19, zinc-binding domain
Zinc finger, RING/FYVE/PHD-type
Zinc finger C2HC RNF-type
Drought induced 19 protein (Di19), zinc-binding
Zinc finger, C3HC4 type (RING finger)
C2HC Zing finger domain
E3 ubiquitin-protein ligase RNF138

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF138 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF138 as an antibody target. Whether an autoantibody or antibody against RNF138 could matter depends on whether native RNF138 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF138 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF138 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...