TRIM8/14/16/25/29/45/65, coiled-coil region

Definition

This entry represents a long helical region connecting domains in TRIM proteins such as TRIM16, TRIM29, TRIM25, TRIM 65, TRIM47, TRIM8 and TRIM14. Many members of this entry act as E3 ubiquitin-protein ligases [[cite:PMID:22629402], [cite:PMID:27981609], [cite:PMID:28747347]]. The TRIM Coiled-Coil (TRIM_CC) domain is a long helical region found in Tripartite Motif (TRIM) proteins, which are part of the RING finger E3 ubiquitin ligase family PMID:23630998. This domain plays a crucial role in protein-protein interactions, particularly in the dimerisation and self-association of TRIM proteins PMID:31406497.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• TRIM14
• TRIM16
• TRIM16L
• TRIM25
• TRIM29
• TRIM47
• TRIM65
• TRIM8