E3 ubiquitin-protein ligase TRIM/RNF

Definition

This family of proteins includes E3 ubiquitin-protein ligases with a role in innate immune defense, particularly against viral infections [[cite:PMID:28469175], [cite:PMID:31006531], [cite:PMID:29038422], [cite:PMID:34512673]]. They mediate ubiquitination of key signalling molecules such as RIG-I and IFIH1/MDA5, which are crucial for the production of interferons in response to viral RNA [[cite:PMID:33849980], [cite:PMID:36045682]]. Some family members also regulate autophagy, inflammation, and cell survival pathways [[cite:PMID:27693506], [cite:PMID:30143514], [cite:PMID:31160576]]. They can ubiquitinate various substrates, influencing processes like mRNA stability, stress granule formation, and protein degradation. The family is characterised by the presence of a RING-type zinc finger domain, which is essential for their ligase activity, and some members have a B30.2/SPRY domain for substrate interaction. They are involved in modulating signal transduction pathways by ubiquitinating different proteins, thus affecting their stability and function.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• RNF135
• TRIM14
• TRIM16
• TRIM25
• TRIM29
• TRIM42
• TRIM47
• TRIM65
• TRIM8