Seroatlas · Human Serome Atlas

UBE2L6

Ubiquitin/ISG15-conjugating enzyme E2 L6

Also known as: UB2L6_HUMAN, UBCH8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14933
Gene: UBE2L6
Ensembl: ENSG00000156587
Chromosome: 11
Canonical length: 153 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>O14933|UBE2L6
     1  MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE
    61  YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP
   121  LRMDLADLLT QNPELFRKNA EEFTLRFGVD RPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2L6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

liver: 126 nTPM
spleen: 119 nTPM
lymph node: 112 nTPM
thymus: 106 nTPM
salivary gland: 97 nTPM
appendix: 87 nTPM

Single-cell type

decidual stromal cells: 254 nCPM
hofbauer cells: 196 nCPM
esophageal basal cells: 106 nCPM
esophageal suprabasal cells: 102 nCPM
kupffer cells: 95 nCPM
megakaryocytes: 87 nCPM

Immune cell

total PBMC: 1,060 nTPM
neutrophil: 842 nTPM
intermediate monocyte: 639 nTPM
non-classical monocyte: 559 nTPM
classical monocyte: 536 nTPM
T-reg: 515 nTPM

Brain region

spinal cord: 90 nTPM
thalamus: 89 nTPM
medulla oblongata: 85 nTPM
hypothalamus: 73 nTPM
midbrain: 73 nTPM
pons: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0.01
gnomAD missense Z: 0.54
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2L6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2L6 as an antibody target. Whether an autoantibody or antibody against UBE2L6 could matter depends on whether native UBE2L6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2L6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2L6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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