Seroatlas · Human Serome Atlas

TNIP3

TNFAIP3-interacting protein 3

Also known as: ABIN-3, FLJ21162, LIND, TNIP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KP6
Gene: TNIP3
Ensembl: ENSG00000050730
Chromosome: 4
Canonical length: 325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of canonical NF-kappaB signal transduction; and pattern recognition receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q96KP6|TNIP3
     1  MAHFVQGTSR MIAAESSTEH KECAEPSTRK NLMNSLEQKI RCLEKQRKEL LEVNQQWDQQ
    61  FRSMKELYER KVAELKTKLD AAERFLSTRE KDPHQRQRKD DRQREDDRQR DLTRDRLQRE
   121  EKEKERLNEE LHELKEENKL LKGKNTLANK EKEHYECEIK RLNKALQDAL NIKCSFSEDC
   181  LRKSRVEFCH EEMRTEMEVL KQQVQIYEED FKKERSDRER LNQEKEELQQ INETSQSQLN
   241  RLNSQIKACQ MEKEKLEKQL KQMYCPPCNC GLVFHLQDPW VPTGPGAVQK QREHPPDYQW
   301  YALDQLPPDV QHKANGLSSV KKVHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

appendix: 6 nTPM
urinary bladder: 3.9 nTPM
tonsil: 3 nTPM
lymph node: 2.4 nTPM
thymus: 1.7 nTPM
lung: 1.6 nTPM

Single-cell type

monocytes: 200 nCPM
t-cells: 106 nCPM
late spermatids: 92 nCPM
endometrial secretory cells: 46 nCPM
early spermatids: 24 nCPM
macrophages: 24 nCPM

Immune cell

memory CD8 T-cell: 6.2 nTPM
naive CD8 T-cell: 2.7 nTPM
gdT-cell: 2.5 nTPM
MAIT T-cell: 1.8 nTPM
memory CD4 T-cell: 1.1 nTPM
T-reg: 0.7 nTPM

Brain region

pons: 6.4 nTPM
medulla oblongata: 4.8 nTPM
cerebral cortex: 3.7 nTPM
white matter: 3.6 nTPM
basal ganglia: 3.1 nTPM
hypothalamus: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.02
gnomAD missense Z: 0.55
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNIP3 as an antibody target. Whether an autoantibody or antibody against TNIP3 could matter depends on whether native TNIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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