Seroatlas · Human Serome Atlas

TMC8

Transmembrane channel-like protein 8

Also known as: EVER2, EVIN2, TMC8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IU68
Gene
TMC8
Ensembl
ENSG00000167895
Chromosome
17
Canonical length
726 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

726 residues, UniProt reviewed canonical sequence.

>Q8IU68|TMC8
     1  MLLPRSVSSE RAPGVPEPEE LWEAEMERLR GSGTPVRGLP YAMMDKRLIW QLREPAGVQT
    61  LRWQRWQRRR QTVERRLREA AQRLARGLGL WEGALYEIGG LFGTGIRSYF TFLRFLLLLN
   121  LLSLLLTASF VLLPLVWLRP PDPGPTLNLT LQCPGSRQSP PGVLRFHNQL WHVLTGRAFT
   181  NTYLFYGAYR VGPESSSVYS IRLAYLLSPL ACLLLCFCGT LRRMVKGLPQ KTLLGQGYQA
   241  PLSAKVFSSW DFCIRVQEAA TIKKHEISNE FKVELEEGRR FQLMQQQTRA QTACRLLSYL
   301  RVNVLNGLLV VGAISAIFWA TKYSQDNKEE SLFLLLQYLP PGVIALVNFL GPLLFTFLVQ
   361  LENYPPNTEV NLTLIWCVVL KLASLGMFSV SLGQTILCIG RDKSSCESYG YNVCDYQCWE
   421  NSVGEELYKL SIFNFLLTVA FAFLVTLPRR LLVDRFSGRF WAWLEREEFL VPKNVLDIVA
   481  GQTVTWMGLF YCPLLPLLNS VFLFLTFYIK KYTLLKNSRA SSRPFRASSS TFFFQLVLLL
   541  GLLLAAVPLG YVVSSIHSSW DCGLFTNYSA PWQVVPELVA LGLPPIGQRA LHYLGSHAFS
   601  FPLLIMLSLV LTVCVSQTQA NARAIHRLRK QLVWQVQEKW HLVEDLSRLL PEPGPSDSPG
   661  PKYPASQASR PQSFCPGCPC PGSPGHQAPR PGPSVVDAAG LRSPCPGQHG APASARRFRF
   721  PSGAEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
108 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 108 nTPM
  • lymph node: 71 nTPM
  • bone marrow: 70 nTPM
  • thymus: 49 nTPM
  • small intestine: 48 nTPM
  • tonsil: 38 nTPM

Single-cell type

  • nk-cells: 173 nCPM
  • t-cells: 161 nCPM
  • b-cells: 140 nCPM
  • neutrophil progenitors: 103 nCPM
  • hofbauer cells: 87 nCPM
  • innate lymphoid cells: 86 nCPM

Immune cell

  • memory CD8 T-cell: 12 nTPM
  • gdT-cell: 12 nTPM
  • memory CD4 T-cell: 9.9 nTPM
  • MAIT T-cell: 8.4 nTPM
  • naive CD4 T-cell: 8.2 nTPM
  • naive CD8 T-cell: 7.6 nTPM

Brain region

  • thalamus: 8.7 nTPM
  • white matter: 7 nTPM
  • medulla oblongata: 5.9 nTPM
  • pons: 5.7 nTPM
  • spinal cord: 5.2 nTPM
  • cerebral cortex: 4.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMC8.

Disease | AllUniProt

Conditions TMC8 is implicated in, by any mechanism.

  • Epidermodysplasia verruciformis 2 (EV2) MIM:618231

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 729 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC8 as an antibody target. Whether an autoantibody or antibody against TMC8 could matter depends on whether native TMC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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