Seroatlas · Human Serome Atlas

AMN1

Protein AMN1 homolog

Also known as: AMN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY45
Gene: AMN1
Ensembl: ENSG00000151743
Chromosome: 12
Canonical length: 258 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q8IY45|AMN1
     1  MPRPRRVSQL LDLCLWCFMK NISRYLTDIK PLPPNIKDRL IKIMSMQGQI TDSNISEILH
    61  PEVQTLDLRS CDISDAALLH LSNCRKLKKL NLNASKGNRV SVTSEGIKAV ASSCSYLHEA
   121  SLKRCCNLTD EGVVALALNC QLLKIIDLGG CLSITDVSLH ALGKNCPFLQ CVDFSATQVS
   181  DSGVIALVSG PCAKKLEEIH MGHCVNLTDG AVEAVLTYCP QIRILLFHGC PLITDHSREV
   241  LEQLVGPNKL KQVTWTVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

testis: 53 nTPM
retina: 42 nTPM
cerebral cortex: 41 nTPM
amygdala: 35 nTPM
hippocampal formation: 30 nTPM
spinal cord: 30 nTPM

Single-cell type

late primary spermatocytes: 572 nCPM
early spermatids: 563 nCPM
neutrophils: 362 nCPM
rod photoreceptor cells: 218 nCPM
late spermatids: 189 nCPM
cone photoreceptor cells: 122 nCPM

Immune cell

neutrophil: 52 nTPM
memory B-cell: 22 nTPM
naive B-cell: 19 nTPM
naive CD4 T-cell: 17 nTPM
T-reg: 13 nTPM
plasmacytoid DC: 12 nTPM

Brain region

white matter: 46 nTPM
cerebral cortex: 42 nTPM
basal ganglia: 39 nTPM
hypothalamus: 36 nTPM
thalamus: 34 nTPM
hippocampal formation: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.33
gnomAD missense Z: 1.25
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of AMN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TASOR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMN1 as an antibody target. Whether an autoantibody or antibody against AMN1 could matter depends on whether native AMN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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