Seroatlas · Human Serome Atlas

INPP5A

Inositol polyphosphate-5-phosphatase A

Also known as: 5PTASE, I5P1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14642
Gene
INPP5A
Ensembl
ENSG00000068383
Chromosome
10
Canonical length
412 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q14642|INPP5A
     1  MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN
    61  YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF
   121  DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL
   181  VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK
   241  SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
   301  ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL
   361  VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPP5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 79 nTPM
  • skeletal muscle: 71 nTPM
  • heart muscle: 70 nTPM
  • basal ganglia: 62 nTPM
  • cerebellum: 61 nTPM
  • colon: 50 nTPM

Single-cell type

  • neutrophils: 814 nCPM
  • b-cells: 193 nCPM
  • vascular smooth muscle cells: 192 nCPM
  • thymocytes: 158 nCPM
  • platelets: 153 nCPM
  • neutrophil progenitors: 148 nCPM

Immune cell

  • basophil: 6.7 nTPM
  • neutrophil: 0.8 nTPM
  • eosinophil: 0.6 nTPM
  • total PBMC: 0.3 nTPM
  • T-reg: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • basal ganglia: 180 nTPM
  • cerebellum: 121 nTPM
  • thalamus: 108 nTPM
  • midbrain: 83 nTPM
  • cerebral cortex: 68 nTPM
  • amygdala: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
1.78
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INPP5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPP5A as an antibody target. Whether an autoantibody or antibody against INPP5A could matter depends on whether native INPP5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPP5A is annotated at the cell surface, where native INPP5A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label INPP5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INPP5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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