Seroatlas · Human Serome Atlas

TMEM100

Transmembrane protein 100

Also known as: FLJ10970, FLJ37856, TM100_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV29
Gene: TMEM100
Ensembl: ENSG00000166292
Chromosome: 17
Canonical length: 134 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in BMP signaling pathway. Located in several cellular components, including endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q9NV29|TMEM100
     1  MTEEPIKEIL GAPKAHMAAT MEKSPKSEVV ITTVPLVSEI QLMAATGGTE LSCYRCIIPF
    61  AVVVFIAGIV VTAVAYSFNS HGSIISIFGL VVLSSGLFLL ASSALCWKVR QRSKKAKRRE
   121  SQTALVANQR SLFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM100 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 180 nTPM

Expression across tissuesHPA

Tissue

lung: 180 nTPM
placenta: 51 nTPM
adipose tissue: 38 nTPM
epididymis: 35 nTPM
stomach: 29 nTPM
breast: 27 nTPM

Single-cell type

lymphatic endothelial cells: 61 nCPM
vascular endothelial cells: 54 nCPM
epididymal principal cells: 53 nCPM
peritubular myoid cells: 50 nCPM
epididymal efferent duct absorptive cells: 47 nCPM
fibroblasts: 41 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 11 nTPM
midbrain: 8.6 nTPM
choroid plexus: 6.4 nTPM
pons: 6.4 nTPM
thalamus: 6 nTPM
basal ganglia: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.53
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 100
Transmembrane protein 100

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM100 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM100 as an antibody target. Whether an autoantibody or antibody against TMEM100 could matter depends on whether native TMEM100 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM100 is annotated at the cell surface, where native TMEM100 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM100 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...