Seroatlas · Human Serome Atlas

MORC2

ATPase MORC2

Also known as: AC004542.C22.1, KIAA0852, MORC2_HUMAN, ZCW3, ZCWCC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6X9
Gene: MORC2
Ensembl: ENSG00000133422
Chromosome: 22
Canonical length: 1032 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

1032 residues, UniProt reviewed canonical sequence.

>Q9Y6X9|MORC2
     1  MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG
    61  GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK
   121  KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFRT
   181  EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF
   241  RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR
   301  IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNRAI TLRREADVKK RIKEAKQRAL
   361  KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV
   421  LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS
   481  SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE
   541  QKQKVPLGTF RKDMKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR
   601  PSTEEPVRRP QRPRSPPLPA VIRNAPSRPP SLPTPRPASQ PRKAPVISST PKLPALAARE
   661  EASTSRLLQP PEAPRKPANT LVKTASRPAP LVQQLSPSLL PNSKSPREVP SPKVIKTPVV
   721  KKTESPIKLS PATPSRKRSV AVSDEEEVEE EAERRKERCK RGRFVVKEEK KDSNELSDSA
   781  GEEDSADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR
   841  WVEKGSEDVR LMKPPSPEHQ SLDTQQEGGE EEVGPVAQQA IAVAEPSTSE CLRIEPDTTA
   901  LSTNHETIDL LVQILRNCLR YFLPPSFPIS KKQLSAMNSD ELISFPLKEY FKQYEVGLQN
   961  LCNSYQSRAD SRAKASEESL RTSERKLRET EEKLQKLRTN IVALLQKVQE DIDINTDDEL
  1021  DAYIEDLITK GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
skeletal muscle: 16 nTPM
blood vessel: 12 nTPM
skin: 9.6 nTPM
tongue: 9.5 nTPM
liver: 9.3 nTPM

Single-cell type

myonuclei: 52 nCPM
early spermatids: 44 nCPM
early primary spermatocytes: 42 nCPM
medullary thymic epithelial cells: 36 nCPM
bergmann glia: 32 nCPM
late primary spermatocytes: 32 nCPM

Immune cell

T-reg: 17 nTPM
naive CD4 T-cell: 15 nTPM
memory CD4 T-cell: 15 nTPM
gdT-cell: 12 nTPM
naive CD8 T-cell: 11 nTPM
MAIT T-cell: 10 nTPM

Brain region

cerebellum: 16 nTPM
midbrain: 13 nTPM
white matter: 13 nTPM
thalamus: 13 nTPM
pons: 13 nTPM
basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MORC2.

Disease | AllUniProt

Conditions MORC2 is implicated in, by any mechanism.

Charcot-Marie-Tooth disease, axonal, type 2Z (CMT2Z) MIM:616688
Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN) MIM:619090

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 1,064 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Charcot-Marie-Tooth disease axonal type 2Z
Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy
Charcot-Marie-Tooth disease
Inborn genetic diseases
MORC2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 3.23
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CW-type
Histidine kinase/HSP90-like ATPase superfamily
Morc, S5 domain 2-like
CW-type Zinc Finger
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Morc6 ribosomal protein S5 domain 2-like
ATPase MORC2, chromo domain-like
ATPase MORC2, chromo domain-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MORC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORC2 as an antibody target. Whether an autoantibody or antibody against MORC2 could matter depends on whether native MORC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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