Seroatlas · Human Serome Atlas

ITGB3BP

Centromere protein R

Also known as: CENPR, CENPR_HUMAN, HSU37139, NRIF3, TAP20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13352
Gene
ITGB3BP
Ensembl
ENSG00000142856
Chromosome
1
Canonical length
177 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q13352|ITGB3BP
     1  MPVKRSLKLD GLLEENSFDP SKITRKKSVI TYSPTTGTCQ MSLFASPTSS EEQKHRNGLS
    61  NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI MEIMQNLSSI QALEGSRELE
   121  NLIGISCASH FLKREMQKTK ELMTKVNKQK LFEKSTGLPH KASRHLDSYE FLKAILN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGB3BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • thymus: 19 nTPM
  • parathyroid gland: 17 nTPM
  • lymph node: 17 nTPM
  • tonsil: 15 nTPM
  • epididymis: 15 nTPM

Single-cell type

  • cardiomyocytes: 1,192 nCPM
  • late primary spermatocytes: 322 nCPM
  • oocytes: 212 nCPM
  • late spermatids: 208 nCPM
  • early primary spermatocytes: 181 nCPM
  • adipocytes: 169 nCPM

Immune cell

  • memory B-cell: 16 nTPM
  • NK-cell: 16 nTPM
  • naive B-cell: 16 nTPM
  • basophil: 14 nTPM
  • T-reg: 12 nTPM
  • naive CD4 T-cell: 11 nTPM

Brain region

  • choroid plexus: 4.3 nTPM
  • cerebral cortex: 2.5 nTPM
  • hypothalamus: 2.1 nTPM
  • medulla oblongata: 2.1 nTPM
  • white matter: 2.1 nTPM
  • cerebellum: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centromere protein R
  • Kinetochore component, CENP-R

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGB3BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGB3BP as an antibody target. Whether an autoantibody or antibody against ITGB3BP could matter depends on whether native ITGB3BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGB3BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITGB3BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITGB3BP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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