SCGN
Secretagogin
Also known as: CALBL, DJ501N12.8, SECRET, SEGN, SEGN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O76038
- Gene
- SCGN
- Ensembl
- ENSG00000079689
- Chromosome
- 6
- Canonical length
- 276 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
276 residues, UniProt reviewed canonical sequence.
>O76038|SCGN
1 MDSSREPTLG RLDAAGFWQV WQRFDADEKG YIEEKELDAF FLHMLMKLGT DDTVMKANLH
61 KVKQQFMTTQ DASKDGRIRM KELAGMFLSE DENFLLLFRR ENPLDSSVEF MQIWRKYDAD
121 SSGFISAAEL RNFLRDLFLH HKKAISEAKL EEYTGTMMKI FDRNKDGRLD LNDLARILAL
181 QENFLLQFKM DACSTEERKR DFEKIFAYYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV
241 DLDKFREILL RHCDVNKDGK IQKSELALCL GLKINPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 44 nTPM
- hypothalamus: 42 nTPM
- pituitary gland: 35 nTPM
- cerebellum: 32 nTPM
- rectum: 17 nTPM
- stomach: 17 nTPM
Single-cell type
- other brain neurons: 50 nCPM
- brain inhibitory neurons: 17 nCPM
- proximal tubule cells: 5.9 nCPM
- neuroendocrine cells: 3.5 nCPM
- brain excitatory neurons: 3 nCPM
- bergmann glia: 2.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 93 nTPM
- cerebellum: 36 nTPM
- hippocampal formation: 28 nTPM
- pons: 9.2 nTPM
- medulla oblongata: 2.6 nTPM
- cerebral cortex: 2.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.35
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SCGN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCGN as an antibody target. Whether an autoantibody or antibody against SCGN could matter depends on whether native SCGN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCGN is annotated as secreted, so native SCGN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SCGN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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