Seroatlas · Human Serome Atlas

ZDHHC13

Palmitoyltransferase ZDHHC13

Also known as: FLJ10852, FLJ10941, HIP14L, ZDH13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUH4
Gene
ZDHHC13
Ensembl
ENSG00000177054
Chromosome
11
Canonical length
622 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q8IUH4|ZDHHC13
     1  MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN CDIVKATQYG
    61  IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF YISKGAVVDQ LGGDLNSTPL
   121  HWAIRQGHLP MVILLLQHGA DPTLIDGEGF SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV
   181  NGQTPLMLSA HKVIGPEPTG FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG
   241  SSLDIQNVKG ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV
   301  ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA FLLSSVFWIF
   361  MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG FTKASEEEKK VNIITLAETG
   421  SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM
   481  VCGWIIYGSF IYLSSHCATT FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN
   541  QLFQIAFLGL TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV
   601  VDWTSQYTMV FHPAREKVLR SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 36 nTPM
  • tonsil: 21 nTPM
  • urinary bladder: 21 nTPM
  • skin: 18 nTPM
  • stomach: 17 nTPM
  • rectum: 17 nTPM

Single-cell type

  • esophageal apical cells: 488 nCPM
  • early spermatids: 189 nCPM
  • neutrophil progenitors: 172 nCPM
  • prostatic hillock cells: 142 nCPM
  • pituitary stem cells: 110 nCPM
  • müller glia: 102 nCPM

Immune cell

  • eosinophil: 33 nTPM
  • basophil: 12 nTPM
  • memory CD8 T-cell: 9.6 nTPM
  • T-reg: 9.4 nTPM
  • memory B-cell: 8.8 nTPM
  • gdT-cell: 8.5 nTPM

Brain region

  • choroid plexus: 9.2 nTPM
  • cerebellum: 8.9 nTPM
  • pons: 7.1 nTPM
  • hypothalamus: 7 nTPM
  • cerebral cortex: 6.3 nTPM
  • medulla oblongata: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC13 as an antibody target. Whether an autoantibody or antibody against ZDHHC13 could matter depends on whether native ZDHHC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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