Seroatlas · Human Serome Atlas

LOXL3

Lysyl oxidase homolog 3

Also known as: LOXL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58215
Gene: LOXL3
Ensembl: ENSG00000115318
Chromosome: 2
Canonical length: 753 aa
Protein class: Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

753 residues, UniProt reviewed canonical sequence.

>P58215|LOXL3
     1  MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
    61  QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
   121  VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR
   181  PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS
   241  FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
   301  PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA
   361  RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS
   421  GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG
   481  NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE
   541  TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS
   601  WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ
   661  GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH
   721  RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LOXL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

placenta: 15 nTPM
bone marrow: 13 nTPM
blood vessel: 13 nTPM
spleen: 9 nTPM
heart muscle: 8.3 nTPM
smooth muscle: 7.6 nTPM

Single-cell type

microglia: 84 nCPM
epicardial cells: 46 nCPM
macrophages: 41 nCPM
müller glia: 37 nCPM
hofbauer cells: 35 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

intermediate monocyte: 12 nTPM
non-classical monocyte: 9.3 nTPM
classical monocyte: 5.9 nTPM
myeloid DC: 3.4 nTPM
total PBMC: 2.6 nTPM
neutrophil: 2.5 nTPM

Brain region

white matter: 13 nTPM
medulla oblongata: 13 nTPM
thalamus: 12 nTPM
spinal cord: 9.5 nTPM
hypothalamus: 9.1 nTPM
pons: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LOXL3.

Disease | AllUniProt

Conditions LOXL3 is implicated in, by any mechanism.

Myopia 28, autosomal recessive (MYP28) MIM:619781

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 538 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Myopia 28, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LOXL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LOXL3 as an antibody target. Whether an autoantibody or antibody against LOXL3 could matter depends on whether native LOXL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LOXL3 is annotated as secreted, so native LOXL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LOXL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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