EGR1

Protein identityUniProt · HPA

UniProt accession

P18146

Gene

EGR1

Ensembl

ENSG00000120738

Chromosome

5

Canonical length

543 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>P18146|EGR1
     1  MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGAPEGSGS
    61  NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL TAESFPDISL NNEKVLVETS
   121  YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS
   181  SASASQSPPL SCAVPSNDSS PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY
   241  PAAKGGFQVP MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG
   301  SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS RSDELTRHIR
   361  IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI CGRKFARSDE RKRHTKIHLR
   421  QKDKKADKSV VASSATSSLS SYPSPVATSY PSPVTTSYPS PATTSYPSPV PTSFSSPGSS
   481  TYPSPVHSGF PSPSVATTYS SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI
   541  EIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

729 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EGR1.

Disease | ImmuneIEDB

Conditions an epitope on EGR1 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.59

gnomAD pLI

0.35

gnomAD missense Z

1.9

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• BMP signaling pathway
• cellular response to gamma radiation
• cellular response to heparin
• cellular response to hypoxia
• cellular response to mycophenolic acid
• circadian regulation of gene expression
• circadian temperature homeostasis
• estrous cycle
• interleukin-1-mediated signaling pathway
• locomotor rhythm
• negative regulation of canonical Wnt signaling pathway
• negative regulation of transcription by RNA polymerase II
• positive regulation of chemokine production
• positive regulation of DNA-templated transcription
• positive regulation of gene expression
• positive regulation of gene expression via chromosomal CpG island demethylation
• positive regulation of hormone biosynthetic process
• positive regulation of interleukin-1 beta production
• positive regulation of miRNA transcription
• positive regulation of transcription by RNA polymerase II
• regulation of neuron apoptotic process
• regulation of progesterone biosynthetic process
• regulation of transcription by RNA polymerase II
• response to glucose
• response to hypoxia
• response to insulin
• response to ischemia
• skeletal muscle cell differentiation
• T cell differentiation
• cellular response to interleukin-8
• glomerular mesangial cell proliferation
• positive regulation of glomerular metanephric mesangial cell proliferation
• positive regulation of post-translational protein modification
• regulation of protein sumoylation

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• double-stranded methylated DNA binding
• hemi-methylated DNA-binding
• histone acetyltransferase binding
• promoter-specific chromatin binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• transcription cis-regulatory region binding
• zinc ion binding

Cellular components

• chromatin
• cytoplasm
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Early growth response, N-terminal
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• Early growth response N-terminal domain
• Early growth response protein 1, C-terminal
• Domain of unknown function (DUF3432)

KeywordsUniProt

• Activator
• Biological rhythms
• Cytoplasm
• DNA-binding
• Isopeptide bond
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of EGR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SNAI1
• SMAD1
• HLTF
• SP1
• CDKN2A