Seroatlas · Human Serome Atlas

PRDX1

Peroxiredoxin-1

Also known as: NKEFA, PAGA, PRDX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06830
Gene
PRDX1
Ensembl
ENSG00000117450
Chromosome
1
Canonical length
199 aa
Protein class
Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q06830|PRDX1
     1  MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS
    61  DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK
   121  ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG
   181  SDTIKPDVQK SKEYFSKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
987 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 987 nTPM
  • liver: 786 nTPM
  • thyroid gland: 752 nTPM
  • midbrain: 735 nTPM
  • kidney: 732 nTPM
  • spinal cord: 729 nTPM

Single-cell type

  • esophageal suprabasal cells: 3,653 nCPM
  • esophageal apical cells: 3,623 nCPM
  • esophageal basal cells: 2,324 nCPM
  • extravillous trophoblasts: 2,279 nCPM
  • hofbauer cells: 1,659 nCPM
  • conjunctival goblet cells: 1,637 nCPM

Immune cell

  • basophil: 471 nTPM
  • T-reg: 439 nTPM
  • total PBMC: 416 nTPM
  • non-classical monocyte: 409 nTPM
  • intermediate monocyte: 368 nTPM
  • classical monocyte: 326 nTPM

Brain region

  • white matter: 567 nTPM
  • medulla oblongata: 463 nTPM
  • spinal cord: 454 nTPM
  • midbrain: 449 nTPM
  • hypothalamus: 435 nTPM
  • cerebellum: 427 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRDX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRDX1 as an antibody target. Whether an autoantibody or antibody against PRDX1 could matter depends on whether native PRDX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRDX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRDX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRDX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...