Seroatlas · Human Serome Atlas

MFSD5

Molybdate-anion transporter

Also known as: HsMOT2, MFSD5_HUMAN, MGC11308, SLC61A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6N075
Gene: MFSD5
Ensembl: ENSG00000182544
Chromosome: 12
Canonical length: 450 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables molybdate ion transmembrane transporter activity. Involved in molybdate ion transport. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q6N075|MFSD5
     1  MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF LALAADWLQA
    61  PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL
   121  TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV
   181  LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL
   241  RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
   301  IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS
   361  MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL
   421  LAVVGLFTVV RHDAELRVPS PTEEPYAPEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

esophagus: 59 nTPM
skin: 58 nTPM
vagina: 29 nTPM
choroid plexus: 27 nTPM
adrenal gland: 27 nTPM
retina: 25 nTPM

Single-cell type

esophageal apical cells: 221 nCPM
esophageal suprabasal cells: 56 nCPM
cytotrophoblasts: 45 nCPM
hofbauer cells: 38 nCPM
syncytiotrophoblasts: 37 nCPM
suprabasal keratinocytes: 36 nCPM

Immune cell

eosinophil: 104 nTPM
basophil: 59 nTPM
memory B-cell: 50 nTPM
naive B-cell: 45 nTPM
myeloid DC: 38 nTPM
MAIT T-cell: 33 nTPM

Brain region

choroid plexus: 19 nTPM
white matter: 19 nTPM
cerebellum: 18 nTPM
thalamus: 17 nTPM
spinal cord: 17 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molybdate ion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

MFS transporter superfamily
Molybdate-anion transporter
Sugar-tranasporters, 12 TM

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MFSD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD5 as an antibody target. Whether an autoantibody or antibody against MFSD5 could matter depends on whether native MFSD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD5 is annotated at the cell surface, where native MFSD5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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