Seroatlas · Human Serome Atlas

RHBDD1

Rhomboid-related protein 4

Also known as: DKFZp547E052, RHBL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEB9
Gene: RHBDD1
Ensembl: ENSG00000144468
Chromosome: 2
Canonical length: 315 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Enables serine-type endopeptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8TEB9|RHBDD1
     1  MQRRSRGINT GLILLLSQIF HVGINNIPPV TLATLALNIW FFLNPQKPLY SSCLSVEKCY
    61  QQKDWQRLLL SPLHHADDWH LYFNMASMLW KGINLERRLG SRWFAYVITA FSVLTGVVYL
   121  LLQFAVAEFM DEPDFKRSCA VGFSGVLFAL KVLNNHYCPG GFVNILGFPV PNRFACWVEL
   181  VAIHLFSPGT SFAGHLAGIL VGLMYTQGPL KKIMEACAGG FSSSVGYPGR QYYFNSSGSS
   241  GYQDYYPHGR PDHYEEAPRN YDTYTAGLSE EEQLERALQA SLWDRGNTRN SPPPYGFHLS
   301  PEEMRRQRLH RFDSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHBDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

thymus: 35 nTPM
testis: 16 nTPM
tonsil: 16 nTPM
parathyroid gland: 16 nTPM
lymph node: 15 nTPM
thyroid gland: 15 nTPM

Single-cell type

plasma cells: 261 nCPM
b-cells: 219 nCPM
podocytes: 167 nCPM
renal collecting duct intercalated cells: 166 nCPM
pituitary stem cells: 164 nCPM
ependymal cells: 161 nCPM

Immune cell

naive B-cell: 25 nTPM
memory B-cell: 22 nTPM
plasmacytoid DC: 21 nTPM
intermediate monocyte: 20 nTPM
myeloid DC: 17 nTPM
T-reg: 16 nTPM

Brain region

white matter: 72 nTPM
basal ganglia: 68 nTPM
thalamus: 63 nTPM
medulla oblongata: 61 nTPM
spinal cord: 60 nTPM
hypothalamus: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHBDD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHBDD1 as an antibody target. Whether an autoantibody or antibody against RHBDD1 could matter depends on whether native RHBDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHBDD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHBDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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