Seroatlas · Human Serome Atlas

DESI2

Deubiquitinase DESI2

Also known as: C1orf121, CGI-146, DESI-2, DESI2_HUMAN, FAM152A, FLJ21998, PNAS-4, PPPDE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSY9
Gene: DESI2
Ensembl: ENSG00000121644
Chromosome: 1
Canonical length: 194 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q9BSY9|DESI2
     1  MGANQLVVLN VYDMYWMNEY TSSIGIGVFH SGIEVYGREF AYGGHPYPFS GIFEISPGNA
    61  SELGETFKFK EAVVLGSTDF LEDDIEKIVE ELGKEYKGNA YHLMHKNCNH FSSALSEILC
   121  GKEIPRWINR LAYFSSCIPF LQSCLPKEWL TPAALQSSVS QELQDELEEA EDAAASASVA
   181  STAAGSRPGR HTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DESI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

testis: 51 nTPM
blood vessel: 23 nTPM
skeletal muscle: 23 nTPM
tongue: 22 nTPM
lung: 22 nTPM
thyroid gland: 22 nTPM

Single-cell type

late primary spermatocytes: 295 nCPM
alveolar cells type 2: 227 nCPM
differentiating spermatogonia: 173 nCPM
early spermatids: 151 nCPM
transitional alveolar cells: 149 nCPM
late spermatids: 145 nCPM

Immune cell

eosinophil: 5.6 nTPM
memory B-cell: 5.2 nTPM
T-reg: 3.2 nTPM
memory CD8 T-cell: 3 nTPM
naive CD4 T-cell: 2.9 nTPM
naive B-cell: 2.8 nTPM

Brain region

choroid plexus: 23 nTPM
cerebellum: 22 nTPM
basal ganglia: 17 nTPM
thalamus: 13 nTPM
hypothalamus: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.85
gnomAD missense Z: 1.91
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DESI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RPS7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DESI2 as an antibody target. Whether an autoantibody or antibody against DESI2 could matter depends on whether native DESI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DESI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DESI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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