IL3RA

Protein identityUniProt · HPA

UniProt accession

P26951

Gene

IL3RA

Ensembl

ENSG00000185291

Chromosome

X

Canonical length

378 aa

Protein class

CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>P26951|IL3RA
     1  MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM
    61  PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS GKPWAGAENL TCWIHDVDFL
   121  SCSWAVGPGA PADVQYDLYL NVANRRQQYE CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS
   181  HILVRGRSAA FGIPCTDKFV VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL
   241  QIQKRMQPVI TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN
   301  TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ NDKLVVWEAG
   361  KAGLEECLVT EVQVVQKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL3RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

27 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.88

gnomAD pLI

0

gnomAD missense Z

-1.5

OntologyGO

Biological processes

• cytokine-mediated signaling pathway
• interleukin-3-mediated signaling pathway
• positive regulation of cell population proliferation

Molecular functions

• cytokine binding
• cytokine receptor activity
• interleukin-3 receptor activity

Cellular components

• external side of plasma membrane
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Short hematopoietin receptor, family 2, conserved site
• Immunoglobulin-like fold
• Type I cytokine receptor, cytokine-binding domain
• Fibronectin type III superfamily
• IL-3 receptor alpha chain, N-terminal
• Interleukin-6 receptor alpha chain, binding
• IL-3 receptor alpha chain N-terminal domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of IL3RA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL3
• RNF41